Paradoxical Sleep - A Study of its Nature and Mechanisms
Michel Jouvet
Progress In Brain Research Vol. 18 Sleep Mechanisms 1965
Evidence of the duality of the states of sleep

(a) EEG and behavioural findings

(b) Phylogenetic findings

(c) Ontogenetic findings

(d) Functional findings

(e) Structural findings

Mechanisms of paradoxical sleep

(a) Producing P.S. as a reflex

(b) Results of deafferentations

(c) Role of the hypothalamus and pituitary

(d) Deprivation of P.S. in the pontile animal

(e) Effects of temperature on P.S. in the pontile animal

(f) Action of gamma-butyrolactone (G.B.L.)

(g) Osmolarity of the blood and paradoxical sleep


(a) Duality of the states of sleep

(b) Mechanisms underlying the appearance of P.S.

Summary and Conclusions



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Figure 17 : Diagram showing deafferentation procedures that do not affect P.S.

(a) Ablation of the cerebellum, midbrain, hypothalamus, pituitary, diencephalon, and telencephalon. (b) Section of the posterior cervical roots from Cl to C6. (c) Section of the spinal cord at C6. (d) Section of the two vagus nerves and of the sino-aortic nerves. (e) Ablation of the two stellate ganglia. (f) Splanchnicectomy and medullo-adrenal curettage.

From D. Jouvet, 1962.

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