Norepinephrine and REM sleep
Pierre-Hervé Luppi , Christelle Peyron, Claire Rampon, Damien Gervasoni, Bruno Barbagli, Romuald Boissard and Patrice Fort
Rapid Eye Movement Sleep pp. 107-122B.N. Mallick, S. Inoue (Editors) Narosa Publishing House 1999

Table of contents

1. Introduction

2. Effect of the application of gaba and glycine antagonists on the activity of the rat locus coeruleus neurons during sleep

3. Glycinergic and gaba-ergic afferent projections to the locus coeruleus

4. Physiological role of the glycinergic inputs to the LC

5. Physiological role of the gaba-ergic inputs to the LC

6. Conclusions and new hypothesis

6. Conclusions and new hypothesis

During SWS, the noradrenergic neurons of the LC would be inhibited by GABA-ergic neurons located in the lateral preoptic area. At the entrance and during PS, a second population of GABA-ergic neurons located in the periaqueductal gray or the dorsal paragigantocellular nucleus would be responsible for the complete cessation of the noradrenergic neurons of the LC during this sleep state. The cranial motoneurons would be inhibited by glycinergic neurons of the parvocellular nucleus and those of the spinal cord by glycinergic neurons from the gigantocellular ventral nucleus and glycinergic interneurons of the intermediate zone of the spinal cord.


This work was supported by INSERM (U480), CNRS (ERS 5645), Université Claude Bernard Lyon I and the 1996 ESRS-Synthélabo European Research Grant. The authors wish to thank C. Guillemort (GFG Co, Pierre-Bénite) for his help in designing the head-restraining system.

Abbreviations used in the text

  • CNS Central Nervous System
  • CTb cholera toxin B subunit
  • DRN dorsal raphe nucleus
  • EEG Electroencephalogram
  • EMG Electromyogram
  • GABA Gamma amino-butyric acid
  • GAD glutamate decarboxylase
  • Gia nucleus gigantocellular alpha
  • GiV nucleus gigantocellular ventral
  • GLY glycine
  • IPSP Inhibitory post-synaptic potential
  • LC Locus coeruleus
  • PS Paradoxical sleep
  • SWS Slow wave sleep
  • W Wakefulness