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| Articles scientifiques divers |
Afferent projections to the rat locus coeruleus demonstrated by retrograde and anterograde tracing with cholera-toxin B subunit and Phaseolus vulgaris leucoagglutinin
Pierre Herve Luppi, Gary Aston-Jones, Hideo Akaoka, Guy Chouvet and Michel Jouvet - Neuroscience 65 (1) : 119-160 (1995)
Thème : Articles scientifiques divers
The aim of this study was to examine the afferents to the rat locus coeruleus by means of retrograde and anterograde tracing experiments using cholera-toxin B subunit and phaseolus leucoagglutinin. To obtain reliable injections of cholera-toxin B in the locus coeruleus, electrophysiological recordin...
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Human insulin gene insertion in mice. Effects on the sleep-wake cycle?
Jean-Louis Valatx, Philippe Douhet and Danielle Bucchini - J. Sleep Res. 8, Suppl. 1, 65-68 (1999)
Thème : Articles scientifiques divers
Recently, insulin synthesis and the presence of an insulin receptor have been demonstrated in the brain. Intracerebroventricular infusion of insulin causes a selective increase in the amount of slow-wave sleep. In the present study, the sleep-wake cycle of transgenic mice, with or without habenular ...
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The Brain Histaminergic System and arousal mechanisms
Lin J. S. - FrenchCorner
Thème : Articles scientifiques divers
The relationship between histamine and sleep goes back as early as the 1930's when antihistamines were discovered in France. This class of drugs, now designated as H1-receptor antagonists, has notoriously been known to cause sedation and drowsiness in man when used in the treatment of allergies. How...
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The Discovery of Cholera-Toxin as a Powerful Neuroanatomical Tool
Pierre Herve Luppi - FrenchCorner
Thème : Articles scientifiques divers
For thirty years, the advances made in our lab in neural mechanisms responsible for the generation of the sleep-waking cycle have been obtained by a multidisciplinary approach and the development of new methods of investigation. Indeed, physiological, neuroanatomical and pharmacological studies have...
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Iontophoretic application of unconjugated cholera toxin B subunit (CTb) combined with immunohistochemistry of neurochemical substances: a method for transmitter identification of retrogradely labeled neurons
Pierre-Herve Luppi, Patrice Fort and Michel Jouvet - Brain Res. 534 (1-2) : 209-224 (1990)
Thème : Articles scientifiques divers
in this report, we demonstrate that cholera-toxin b subunit (ctb) is a very sensitive retrograde tracer in the central nervous system when recognized by streptavidin-peroxidase immunohistochemistry. we further show that: (1) injection of a small volume of ctb gives rise to small sharply defined inje...
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