Figure 2 : Effects of p-chlorophenylalanine on sleep and brain concentrations
of serotonin in the rat
After intraperitoneal injection (500 milligrams per kilogram), there
is a decrease in the amount of slow wave sleep (SWS) and in serotonin
(5 HT) concentration, followed by a slow return to normal values after
268 hours.
(Solid line) Percentage of slow-wave sleep relative to the amount for
a control rat; each point represents the mean percentage per 12-hour period
(black dots at top in dicate night hours, 7 p.m. to 7 a.m. ) .
(Dashed line) Percentage of serotonin (relative to the concentration
for a control rat); for the purpose of this analysis, two animals were
killed every 12 hours.
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