Automatic deprivation of P.S. in the pontile animal

Paradoxical Sleep - A Study of its Nature and Mechanisms

Michel Jouvet
Progress In Brain Research Vol. 18 Sleep Mechanisms 1965

TABLE OF CONTENTS

Introduction

Evidence of the duality of the states of sleep

(a) EEG and behavioural findings

(b) Phylogenetic findings

(c) Ontogenetic findings

(d) Functional findings

(e) Structural findings

Mechanisms of paradoxical sleep

(a) Producing P.S. as a reflex

(b) Results of deafferentations

(c) Role of the hypothalamus and pituitary

(d) Deprivation of P.S. in the pontile animal

(e) Effects of temperature on P.S. in the pontile animal

(f) Action of gamma-butyrolactone (G.B.L.)

(g) Osmolarity of the blood and paradoxical sleep

Discussion

(a) Duality of the states of sleep

(b) Mechanisms underlying the appearance of P.S.

Summary and Conclusions

Figures

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Figure 21 : Automatic deprivation of P.S. in the pontile animal

Slow-speed recording. Disappearance of EMG activity in the neck on incipient P.S. produces an electric shock (artefact) which wakes the animal for some 10 sec until P.S. inevitably sets in once again (5th h of deprivation). PRF: Activity of the pontine reticular formation. Note the appearance of eye movements (EM) as EMG activity falls.

Scale: 3 sec; 50 microV.