Paradoxical Sleep - A Study of its Nature and Mechanisms
Michel Jouvet
Progress In Brain Research Vol. 18 Sleep Mechanisms 1965
Evidence of the duality of the states of sleep

(a) EEG and behavioural findings

(b) Phylogenetic findings

(c) Ontogenetic findings

(d) Functional findings

(e) Structural findings

Mechanisms of paradoxical sleep

(a) Producing P.S. as a reflex

(b) Results of deafferentations

(c) Role of the hypothalamus and pituitary

(d) Deprivation of P.S. in the pontile animal

(e) Effects of temperature on P.S. in the pontile animal

(f) Action of gamma-butyrolactone (G.B.L.)

(g) Osmolarity of the blood and paradoxical sleep


(a) Duality of the states of sleep

(b) Mechanisms underlying the appearance of P.S.

Summary and Conclusions



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Figure 14 : Pontine animal with hypothalamic island

EEG recorded 89 days after operation. The four tracings represent uninterrupted consecutive activity. Above: Arousal followed by paradoxical sleep with typical monophasic spikes at the pontine level (PRF), eye movements (EM) and total depression of muscular activity in the neck (EMG). The fourth tracing represents.the end of paradoxical sleep. Each line represents 2 min of recording.

Calibration 6 sec, 50 microV.

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